Chanel N°22 was the second perfume Ernest Beaux made for Gabrielle Chanel, released the year after N°5. Like N°5 it took a number for a name, in this case a reference to its year of creation, 1922. Chanel's own history says it was inspired by the same revolutionary spirit as N°5 and describes it as a powdery floral carried by tuberose.

Wikipedia classes it as a floral aldehyde, with aldehydic top notes, a heart of jasmine, tuberose, ylang-ylang and rose, and a base of vetiver, vanilla and incense. The New Yorker cartoonist Ralph Barton was said to wear it.

The house perfumer Jacques Polge reformulated N°22 in 1989, and a lighter, alcohol-free voile version followed in 1996. In February 2007 it was reissued as part of Les Exclusifs de Chanel, the line sold only in Chanel boutiques and a few select stores.