Lola Prusac was born in Poland on 18 January 1895 and made her career in Paris, where she became known for an inventive, original approach to dressing.

She joined Hermès in 1925, at a moment when the saddler was opening itself to new métiers, initially in the unusual post of counsellor for colour and then as a designer. In 1929 she designed the house's first collection for women. She also worked on early silk squares, and in the early 1930s created bags with geometric inlays inspired by the paintings of Piet Mondrian, a striking modernist note for a house rooted in equestrian leather.

She left Hermès in 1935 and the following year founded her own house, specialising in what the French called sport-tricot, casual knitted clothing. She was a member of the Chambre Syndicale de la Haute Couture from 1942, but in 1952 the body declined to grant her house couture-création status because of its emphasis on knitwear. In 1978 her contribution was recognised with an Aiguille d'Or, the golden needle award.

Lola Prusac died on 29 October 1985.