Karl-Friedrich Scheufele was born on 5 February 1958 in Pforzheim, the son of Karl and Karin Scheufele, and lived there until he was fifteen. He joined Chopard in the 1980s and set out to give it its own high-precision mechanical movements: Chopard Manufacture opened in Fleurier, in the Val-de-Travers, in 1996, and produced the L.U.C 1.96, the house's first in-house movement of the modern era. With Michel Parmigiani he founded the Fleurier Quality Foundation, an independent certification body, in 2005, and in 2006 opened the L.U.CEUM watch museum in Fleurier. He acquired the Ferdinand Berthoud name in 2006 and relaunched it as Chronométrie Ferdinand Berthoud in 2015.
He has been co-president of Chopard with his sister Caroline since 2001. A wine enthusiast, he founded the wine merchant La Galerie des Arts du Vin in 1996 and in 2012 bought Château Monestier La Tour near Bergerac.